ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis inPseudomonas aeruginosa

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ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa.

AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa. However, the regulon and molecular regulatory mechanism of AlgR have yet to be fully elucidated. Here, among 157 loci that were identified by a ChIP-seq assay, we characterized a gene, mucR, which encodes an enzyme that synthesizes the...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2015

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gkv747